Sodium Pyruvate: Cellular, Biochemical and Pharmacology Background

Biochemical and Pharmacology Background

Sodium Pyruvate is biochemically classified as an α-ketoacid and is part of the body’s natural endogenous anti-oxidant defense system. It is secreted by cells, readily enters cells, and can directly react to detoxify detrimental compounds such as H2O2 and peroxynitrites. Sodium Pyruvate has been shown to significantly reduce inflammatory agents in all parts of the human body including the lungs and the nasal cavities. The inflammatory agents being reduced include hydrogen peroxide, nitric oxide, IL-8, TNF, and other inflammatory cytokines, that are produced by oxygen radicals.

Animal Safety Studies: Rat Study for 180 Days - Nose Only Inhalation Study

Animal Safety Studies

The rats were given more than 10X the 5mM dosages used in human inhalation studies. If you include the difference in body weights of humans vs. rats the concentrations tested were 100X the 5mM concentrations. After 180 days, the remaining rats from each group were sacrificed. As before, at necropsy, gross morphological observations on lung, liver, kidney, heart, and body weights were recorded. Histopathological evaluations were performed on lung, trachea, larynx, nose, liver, heart, and kidneys.

Safety of Pyruvate for Nasal Products and List of Products with Pyruvate

Sodium Pyruvate

Sodium Pyruvate is a natural and ubiquitous biochemical antioxidant component of the human mammalian system that is critical to cells and the survival of mitochondria, the power house of all living cells. It is involved in a myriad of biochemical reactions, and is a critical and necessary component involved in the biochemical cascade leading to the Krebs Cycle reactions.